
Neurolixis Publishes Positive Phase 2A Trial Results for NLX-112 in Parkinsonโs Disease

NLX-112 Shows Groundbreaking Dual Efficacy in Reducing Levodopa-Induced Dyskinesia and Parkinsonian Motor Symptoms
The randomized, double-blind, placebo-controlled trial, supported by The Michael J. Fox Foundation and Parkinsonโs UK, evaluated NLX-112 in patients with troubling LID. The study successfully met its primary endpoint of safety and tolerability, as well as its secondary endpoint of significantly reducing LID. Notably, NLX-112 also demonstrated anti-parkinsonian effects, significantly improving motor function in study participants. The full publication is available with Open Access:
๐ก๐๐ซ-๐ญ๐ญ๐ฎ ๐ฟ๐ฎ๐ป๐ฑ๐ผ๐บ๐ถ๐๐ฒ๐ฑ ๐ฃ๐ต๐ฎ๐ ๐๐ฟ๐ถ๐ฎ๐น: ๐๐ฎ๐ณ๐ฒ๐๐, ๐๐ผ๐น๐ฒ๐ฟ๐ฎ๐ฏ๐ถ๐น๐ถ๐๐, ๐ฎ๐ป๐๐ถ-๐ฑ๐๐๐ธ๐ถ๐ป๐ฒ๐๐ถ๐ฐ ๐ฎ๐ป๐ฑ ๐ฎ๐ป๐๐ถ-๐ฝ๐ฎ๐ฟ๐ธ๐ถ๐ป๐๐ผ๐ป๐ถ๐ฎ๐ป ๐ฒ๐ณ๐ณ๐ถ๐ฐ๐ฎ๐ฐ๐.
๐๐ฐ๐ท๐ฆ๐ฎ๐ฆ๐ฏ๐ต ๐๐ช๐ด๐ฐ๐ณ๐ฅ๐ฆ๐ณ๐ด, 2025 (https://doi.org/10.1002/mds.30175)
๐๐ฟ. ๐๐ฑ๐ฟ๐ถ๐ฎ๐ป ๐ก๐ฒ๐๐บ๐ฎ๐ป-๐ง๐ฎ๐ป๐ฐ๐ฟ๐ฒ๐ฑ๐ถ, CEO of Neurolixis, commented: โWe are pleased to make the detailed results of the trial publicly available. NLX-112โs reduction of both dyskinesia and parkinsonism represents a potential paradigm shift in Parkinsonโs treatment. Its first-in-class mechanism of action, selectively targeting the serotonin system rather than dopamine, offers a novel approach that could significantly improve the lives of patients.โ
๐ ๐ก๐ผ๐๐ฒ๐น ๐ ๐ฒ๐ฐ๐ต๐ฎ๐ป๐ถ๐๐บ ๐ผ๐ณ ๐๐ฐ๐๐ถ๐ผ๐ป
Unlike current Parkinsonโs treatments that target the dopamine system, NLX-112 acts on the serotonin (5-HT) system, as a highly selective full activator of 5-HT1A receptors. This unique mechanism differentiates NLX-112 from previous serotonergic drugs and is believed to underlie its dual efficacy in reducing dyskinesia and improving motor function. The promising results from this Phase 2A trial support further development of NLX-112 as a transformative therapy for movement disorders. Neurolixis is actively planning next steps in the clinical development program to advance NLX-112 toward potential regulatory approval.
๐๐ฏ๐ผ๐๐ ๐ฃ๐ฎ๐ฟ๐ธ๐ถ๐ป๐๐ผ๐ปโ๐ ๐๐ถ๐๐ฒ๐ฎ๐๐ฒ ๐ฎ๐ป๐ฑ ๐ฅ๐ฒ๐น๐ฎ๐๐ฒ๐ฑ ๐ ๐ผ๐๐ฒ๐บ๐ฒ๐ป๐ ๐๐ถ๐๐ผ๐ฟ๐ฑ๐ฒ๐ฟ๐
Parkinsonโs disease is the second most common neurodegenerative disorder, affecting over 10 million people worldwide. Levodopa, the mainstay treatment for Parkinsonโs, often leads to debilitating dyskinesias (involuntary movements) after prolonged use. Up to 80% of patients develop LID within ten years of levodopa therapy. Current treatments for LID, such as amantadine, are limited by side effects and variable efficacy, underscoring the need for new therapeutic options.
As well as Parkinsonโs disease, other disorders also involve dysfunction in the basal ganglia, a brain region critical for coordinating movement. Such disorders include spinocerebellar ataxia, Huntingtonโs disease, essential tremor and dystonia, and lead symptoms such as tremors, rigidity, and impaired motor control.
๐๐ฏ๐ผ๐๐ ๐ก๐ฒ๐๐ฟ๐ผ๐น๐ถ๐ ๐ถ๐
Neurolixis is a biopharmaceutical company dedicated to developing innovative therapies for central nervous system disorders, including Parkinsonโs disease, autism spectrum disorders, pain, and depression. The companyโs drug candidates are serotonin 5-HT1A receptor โbiased agonistsโ, designed to target specific brain regions for enhanced therapeutic effects.
NLX-112 has previously shown favorable safety and tolerability in over 600 subjects across Phase 1 and Phase 2 trials for other indications. In addition to Parkinsonโs disease, NLX-112 is being investigated as a potential treatment for spinocerebellar ataxia, a rare motor disorder. Neurolixisโ pipeline also includes NLX-101, a Phase 1 candidate for rare autism spectrum disorders (Rett syndrome and Fragile X syndrome), and NLX-204, a preclinical candidate for pain and mood disorders.
For more information, email contact@neurolixis.com.
ADRIAN NEWMAN-TANCREDI
NEUROLIXIS
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